Additionally, another exception occurred while executing the custom error page for the first exception. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Psychotropic meds chloroquine Is plaquenil safe to use Hydroxychloroquine and skin darkening Plaquenil depression Retinal damage – There is a small chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen. For this reason, you should see your ophthalmologist at least once per year so that she/he may check for retinal deposits. Chloroquine and hydroxychloroquine bind to melanin in the retinal pigment epithelium RPE and cause damage to the macular cones outside of the fovea. The drugs inhibit RPE lysosome activity, reduce phagocytosis of shed photoreceptor outer segments causing an accumulation of outer receptor segments. Find information about common, infrequent and rare side effects of Plaquenil Oral. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine and retinal deposit Hydroxychloroquine Professional Patient Advice -, Chloroquine And Hydroxychloroquine Toxicity - StatPearls. Malaria chloroquine tabletsPlaquenil pill sjogren'sCan hydroxychloroquine cause diarrhea Retinal screening service will be provided by STH Ophthalmology department As patients are started on hydroxychloroquine, they will have a baseline retinal screen usually at 3 months but certainly within 12 months of starting, organised by the specialist. The specialist will also arrange a follow up retinal screen after 5 years Hydroxychloroquine and Retinal Screening. Common and Rare Side Effects for Plaquenil Oral. Retinal Physician - Hydroxychloroquine Maculopathy An Update.. Effectiveness of Chloroquine and Hydroxychloroquine in Treating Selected Patients With Sarcoidosis With Neurological Involvement. retinal deposits without any. Severe and irreversible retinal damage has been reported with the use of hydroxychloroquine. Risk factors for retinal damage include daily doses more than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than 5 years, subnormal glomerular filtration, use of concomitant drugs such as tamoxifen, and concurrent macular disease. Deposits in these cells can lead to cutaneous pigmentation and possibly retinal toxicity. Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine.