I am currently taking 200mg one time a day and my appetite has seriously decreased in the last two weeks. Just curious if anyone else had this as a side effect. Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. I was not losing weight or have a lack of appetite prior to Plaquenil so it must be the medicine. I personally had terrible nausea for almost 2 years when I was put on plaquinel, the nausea was the first symptom to leave....causing me to gain weight. I just find Im not as hungry as I was before, or that my appetite has changed. Eye 5est to check eyes when taking plaquenil Hydroxychloroquine sulfate 200 mg side effects Hydroxychloroquine and sle Hydroxychloroquine 200 mg discount The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. According to the Mayo Clinic, the daily dose for RA is based on body weight; the dose is 2.9mg per pound 1. This means many people taking Plaquenil for RA are taking a dose of 400mg a day or higher. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. Plaquenil and weight loss. Hollywood8687 02/27/2014. I recently went on Plaquenil a few months ago, and I have been noticing how much weight I've been losing. I feel like I am losing too much weight. I am a thin person, and I am sick very often. Last week, I lost three pounds, and the week before I lost two pounds. In this case, the cause of loss f appetite and weight loss has to be found. I was just curious if the medication was what caused my appetite to change or what. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. At my last visit my Dr asked me if it had deminished my appetite so she is aware of it and the amount of weight I lost and is not concerned at this moment. I know diarhea is a common side affect of plaquinel. It wasn't that I was eating a lot, it was just that I was actually eating. I was on Prednisone for two months prior to Plaquenil and gained 18 lbs, so I needed to lose the weight anyway. Losing weight off of plaquenil Plaquenil Hydroxychloroquine - Side Effects, Dosage., Common and Rare Side Effects for Plaquenil Oral Weight based dosing plaquenilHydroxychloroquine treatment for lyme disease Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil and weight loss DailyStrength. Let me tell you what weaning down from Plaquenil is like.. Removing the Plaquenil to 3 days a week hasn't take away the pain. Due to new insurance protocols in our state, we have had a month of switching doctors not all his doctors take the new insurance and he will now have a new Rheumatologist. I also have an open invitation to Dr Medsgar's, a Scleroderma specialist. Plaquenil and Depression/Anxiety. I was diagnosed with Sjogren’s a year ago Early Sjogren’s Panel by the doctor I see for Ehlers-Danlos Syndrome. I started at a very low dose- 100mg per day 1/2 of a 200 mg tablet, in addition to a small dose of modafinil I was taking for fatigue, which is my worst symptom. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur.