Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Is hydroxychloroquine used for osteoarthritis Chloroquine euthanasia Hydroxychloroquine erg One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Feeling that others can hear your thoughts feeling, seeing, or hearing things that are not there fever with or without chills general feeling of tiredness or weakness headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause headaches Common and Rare Side Effects for Plaquenil Oral, Plaquenil Side Effects Common, Severe, Long Term - Plaquenil retinal damageAralen genericoSafe dosage of plaquenilChloroquine resistant malaria in pregnant Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Long-Term Side Effects of Plaquenil for Rheumatoid.. I take plaquenil for RA, MCTD, etc. it worsens headache that are daily 24/7. Most drugs I took for AI diseases, prescribed by my rheumy, worsened headaches. The headaches range from mild to migraine, to dizzying. My neurologist is now evaluating me for a cerebral spinal fluid leak which can cause positional headache. Thanks for your advice, Shani. The headaches were just bad headaches and stopped when I started taking Plaquenil at night instead of the morning. The blurred vision came separately and went a day or two after I stopped the Plaquenil again. As it happens, my GP phoned me today about something else and I told her about this. In addition, since responses to stress can cause physical symptoms such as headache, increased pain, and muscle tension, try to practice stress management skills. There are some stressors that you can control, and there are some that are simply out of your hands.