Chloroquine and hydroxychloroquine in cancer therapy

Discussion in 'Canada Pharmacy Online' started by Agapov, 25-Feb-2020.

  1. well-work Guest

    Chloroquine and hydroxychloroquine in cancer therapy


    The clinical trials on this list are studying Hydroxychloroquine. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease.

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    Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Hydroxychloroquine is used widely for the treatment of systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatologic conditions. Cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation 28. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, During the last decade research is gradually repositioning the antimalarial drug chloroquine, and certain related quinoline derivatives, as anticancer agents. Chloroquine and hydroxychloroquine, in particular, have relatively wellcharacterized toxicity profiles due to several decades of use for treatment of malaria.

    Talk to your doctor for help in deciding if one is right for you. You may want to think about taking part in a clinical trial.

    Chloroquine and hydroxychloroquine in cancer therapy

    Chloroquine plaquil combinations - Ovarian cancer - Inspire, Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy

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  4. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells.

    • Chloroquine & Hydroxychloroquine supporting chemo..
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    • ReDO hydroxychloroquine as anti-cancer agents Anticancerfund.

    As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Accordingly, inhibitors of autophagy including chloroquine and hydroxychloroquine have been shown to mediate substantial antineoplastic effects in preclinical models, especially when combined with chemo- or radiotherapeutic interventions. Quine CQ and hydroxychloroquine HCQ, are 4-aminoquinoline-based compounds that have been used for the prevention and treatment of malaria. They have also been used as anti-inflammatory agents for treating rheumatoid arthritis, and lupus erythematosus.1 CQ is one of the most prominent cases of drug repurposing in cancer2 and it was introduced as an auxiliary anticancer

     
  5. Gromm Well-Known Member

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Plaquenil - does it take long time to work? - Lupus - Inspire Plaquenil Use in Autoimmune Diseases Plaquenil.long do I have to wait? DailyStrength
     
  6. mstar Guest

    Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy Chloroquine is sometimes tolerated by patients who do not tolerate hydroxychloroquine. Ophthalmologic retinal and visual field testing should be performed at baseline or soon after drug initiation and then at 6 -12 month intervals.

    Chloroquine Oral Route Proper Use - Mayo Clinic
     
  7. Svonochka Well-Known Member

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses.

    Hydroxychloroquine Side Effects -