Chloroquine major issue

Discussion in 'Canadian Pharmacies Without An Rx' started by Mikhael-SM, 19-Mar-2020.

  1. xenoncar XenForo Moderator

    Chloroquine major issue


    It is similar to CQ in practically any way, although its similar efficacy against COVID-19 would still be an assumption. So far I have found these: There are about 10 clinical trials in China looking at hydroxychloroquine for COVID, including some comparing it with chloroquine phosphate.

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    The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration. Both chloroquine and hydroxychloroquine are used off-label for rheumatoid arthritis and for lupus, but how they work in these areas is another shoulder-shrugger, and there are side effects in the eye. It’s been suggested as an adjunct in some cancer therapy regimes, but there are problems there, too, in the kidney. As HCoVs are no longer considered to be as harmless as previously assumed and as they can be associated with severe respiratory tract infections, the identification of compounds effective against these viruses is an important issue. Chloroquine is a clinically approved drug effective against malaria, and it is known to elicit antiviral effects.

    You can search the Chinese clinical trial database here (type "hydroxychloroquine" into the Public Title field): HCQ prevents dengue virus infection in vitro. Don't worry, the studies are being done and the data will be out soon.

    Chloroquine major issue

    Aquarium Fish Chloroquine A "New" Drug for Treating Fish Diseases., Chloroquine, Past and Present In the Pipeline

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  7. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools.

    • Recommendations on Screening for Chloroquine and..
    • Antiviral Activity of Chloroquine against Human Coronavirus..
    • Chloroquine and other repurposed drugs in the treatment of..

    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Patients are at low risk during the first 5 years of treatment. Other major risk factors include renal disease, concominant drug use e.g. tamoxifen, and macular disease which is thought to potentially affect screening and susceptibility to Plaquenil and chloroquine.

     
  8. seonovice Moderator

    The following information is NOT intended to endorse any particular medication. Chloroquine MedlinePlus Drug Information Chloroquine Oral Route Proper Use - Mayo Clinic Chloroquine Uses, Side Effects & Warnings -
     
  9. zxx Moderator

    Quinine was frequently prescribed as an off-label treatment for leg cramps at night, but this has become less common due to a warning from the US Food and Drug Administration (FDA) that this practice is associated with life-threatening side effects. Comparative study of chloroquine and quinine on malaria. Chloroquine and Quinine - ResearchGate Quinine Uses, Side Effects & Warnings -
     
  10. Mypaku XenForo Moderator

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