In fact, most people with lupus have fatigue at some point in their illness. “When lupus hit, it was like running into a wall at 80 mph,” says Ann S. Hydroxychloroquine pharmacotherapy Plaquenil pregnancy drug class Chloroquine dosing retina recommendation Inappropriate malaria prophylaxis chloroquine resistant I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. I think that Plaquenil helped me with fatigue althjough I can still sleep for 12 hours straight at a weekend. 200mg Plaq didn't help - 400md did. It took at least 6 months for me to notice a difference. Taking thyroid meds as well may have helped in my case - but I think it helped more with depression. Rheumy started me on plaquenil and it helped with the tiredness and no energy for a while but it did not do anything for dry eyes/saliva at all so why take it. It is supposed to slow down the immune system so your problems aren't as bad.i.e. tears/saliva. But, I started getting bronchitis in Jan-April. “I had been very active my whole life, and the fatigue just knocked me flat. Utterback, Ph D, a broadcast voice specialist in Virginia who was diagnosed with lupus in 2006. Does plaquenil help with fatigue Ask the Expert Plaquenil and Sjögren’s, Did Plaquenil help your fatigue? - Sjogren's World Dose of chloroquine to inhibit autophagyPlaquenil which companyCan i tan on plaquenilHydroxychloroquine human antihimeric antibodies Plaquenil hydroxychloroquine helps inflammation, will that help with fatigue in sarcoidosis? Plaquenil hydroxychloroquine helps inflammation, will that.. Hydroxychloroquine User Reviews for Sjogren's. -. Is extreme fatigue a side effect of Plaquenil - NRAS. Yes, plaquenil should help with all or most lupus symptoms, fatigue, pain, rashes, etc. Here is a link to my blog about lupus meds. If side effects do occur, they are usually minor and last only for a short period of time. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. NSAIDs alone didn't help my daughter, but adding 5-Loxin was a game changer for her. Immune cells on the attack produce prostaglandins and leukotrienes and sometimes histamine. Medicines that inhibit these can help slow down the autoimmune response and provide symptom relief while DMARDs like Plaquenil need time to work.