Please review the following URL and make sure that it is spelled correctly. Requested URL: /drugsatfda_docs/label/2017/009768s... Massive hydroxychloroquine overdose Plaquenil annual eye exam Hyperpigmentation of the skin due to hydroxychloroquine My understanding about Plaquenil is the doses taken for autoimmune disease is far less then that for Malaria, and even then the incident of neuropathy with malaria dosing is very low. Plaquenil and small fiber neuropathy. I used Plaquenil years ago for extreme muscle and joint issues and it seemed to work fine. All my issues were resolved over a years time on low doses. I believe my problems started with side effects of a statin, which I stopped taking during my Plaquenil treatment but resumed after symptoms were resolved. Lupus is a broad term for several autoimmune disorders that weaken the body’s immune system by producing antibodies that attack healthy cells, tissues and organs. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Chloroquine neuropathy Chloroquine - an overview ScienceDirect Topics, Plaquenil and small fiber neuropathy - NeuroTalk Support. Quinacrine chloroquine antimalarial alkaloidSide effects of plaquenil for lupusAtp quantification assay chloroquineMalarone for chloroquine resistance ncbi Four patients were observed who developed similar episodes of peripheral neuropathy following prolonged treatment with chloroquine phosphate. This previously unreported toxic reaction consisted of bilateral loss of knee and ankle reflexes and weakness of the quadriceps muscles. Gradual return to normal followed withdrawal of the chloroquine. Peripheral Neuropathy Following Chloroquine Therapy. Systemic Lupus Erythematosus The Foundation For Peripheral.. Toxic neuropathies. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Did your muscle pain come before, after or with the neuropathy? Did the Plaquenil help with the muscle joint part of your problem? Where was your neuropathy and what are you taking now if anything? When I took the Plaquenil I had RA antibodies and it was muscle / joint related. Thanks for responding. Toxic optic neuropathy TON refers to visual impairment due to optic nerve damage caused by a toxin. Toxic optic neuropathy is characterized by bilateral, usually symmetric vision loss, papillomacular bundle damage, central or cecocentral scotoma, and reduced color vision.