Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. What does chloroquine do in gel Liquid plaquenil With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. When I started Plaquenil back in November last year, I had terrible headaches which started about 1/2 an hour after taking pills. It happened so consistently that I started taking tylenol when I would take it. I would lay down with an ice pack under my neck and darken the room. After about 30min of resting with the ice pack. Plaquenil is in a class of medicines known as antimalarials. It's a less toxic version of the older antimalarials, including quinine and chloroquine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil less headaches Ice Pick Headaches Causes, Treatments, and Symptoms, Plaquenil and headaches DailyStrength Can plaquenil cause weight lossNatural substitute for plaquenil for discoid lupusCan hydroxychloroquine get you highSymptoms of plaquenil toxicity Plaquenil hydroxychloroquine "I’ve been on plaquenil 400mg once a day for 6 months now due to Sjogrens. If your are wondering how long the plaquenil takes to work, it took about 3 months before I starting feeling better. Now at 6 months I’m noticing more symptoms. Hydroxychloroquine User Reviews for Sjogren's. -. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. PLAQUENIL Side Effects, Reviews by Patients -. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. You will likely have to take additional medications to keep your rheumatoid arthritis in control. Yes, I have migraines too and when i was taking plaquenil they increased significantly. Took me the longest time to figure out what it was but I decided to ask my rheumatologist about it and she said that was rare but possibly could be causing them to be more frequent so we went off the plaquenil and they slowly became less frequent. Jan 11, 2012 I have been on the plaquenil 200 mgm for about 4 months now. I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Noticed nothing different. Plaquenil isn a antiparasitic drug with anti-inflammatory affect.