Chloroquine cancer clinical trials

Discussion in 'Chloroquine Drug' started by Lucky, 13-Mar-2020.

  1. LorDros Guest

    Chloroquine cancer clinical trials


    Listing a study does not mean it has been evaluated by the U. One of the mechanisms responsible for survival of these therapy-resistant hypoxic cells is (macro-)autophagy: a phenomenon in which cells provide themselves with energy (ATP) by digesting their own cell-organelles. Tumor hypoxia is a well-known factor negatively influencing outcome in many solid tumors, including small cell lung cancer.

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    These findings support clinical study of chloroquine to lower rates of venous thromboembolism in patients with cancer. Trial registration. This study reports correlative data from two clinical trials that registered with clinicaltrials.gov, NCT01128296 May 21, 2010 and NCT01978184 November 7, 2013. Chloroquine data from Covid-19 trials Data from the drug’s studies showed ‘certain curative effect’ with ‘fairly good efficacy’. According to Sun, patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups. Abstract. The PINC trial NCT01023477 examined the dosage efficacy of oral chloroquine CQ, an autophagy inhibitor, as a neoadjuvant therapy to reduce the volume, cause regression and decrease the recurrence of breast ductal carcinoma in situ DCIS, for any grade or ER/PR/Her2 status.

    Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy.

    Chloroquine cancer clinical trials

    Chloroquine in Cancer Therapy A Double-Edged Sword. - Cancer Research, Coronavirus Covid-19 Chloroquine data; Japan to trial HIV drug

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  3. A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer CUBiC. The breast cancer tissue collected and stored during this clinical trial will offer a unique opportunity to study the effect of CQ on the biology of human breast tissue. RNA and gene expression levels will be extracted from participant.

    • A Phase 2 Randomized, Double-blind Trial Evaluating the..
    • Abstract CT140 PINC trial Preventing invasive. - Cancer Research.
    • Chloroquine & Hydroxychloroquine supporting chemo..

    Per Xinhua, a Chinese state news agency, there was a Feb. 17 report that “Chinese experts, based on the result of clinical trials, have confirmed that chloroquine phosphatehas a certain. The potential of metformin and chloroquine as adjuvant drugs was recently demonstrated in vivo, where metformin or chloroquine had a sensitising and/or synergistic antitumour effect in combination with temozolomide,39 40 cisplatin41 42 and gemcitabine43 44 in xenograft models or proof-of-concept clinical trials of various types of human cancer. Clinical trials are research studies that involve people. The clinical trials on this list are studying Hydroxychloroquine. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease.

     
  4. Bill Gates Guest

    Applies to chloroquine: oral tablet Along with its needed effects, chloroquine may cause some unwanted effects. Chloroquine Side Effects Common, Severe, Long Term - OKAP and Board Review - American Academy of Ophthalmology Plaquenil - Antirheumatic Agents, Antimalarials, Amebicides.
     
  5. 2ivank Moderator

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  6. sparov User

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs
     
  7. chefa Moderator

    Plaquenil Oral Uses, Side Effects, Interactions. How to use Plaquenil Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy.

    Plaquenil - FDA prescribing information, side effects and uses