Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Plaquenil dissolving immune complexes Plaquenil eye toxicity Methylprednisolone and hydroxychloroquine Oct 09, 2015 Methotrexate or Plaquenil In Scleroderma Foundation Ok, here is a question that we all could probably use an answer to; Methotrexate or Plaquenil for CREST Scleroderma. Hydroxychloroquine Plaquenil® is used for rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine Plaquenil® is an antibiotic used to treat malaria, but it also works to treat symptoms of RA, lupus, and other rheumatic diseases. It can reduce your joint pain and swelling. When monotherapy with a synthetic DMARD isn’t working well enough, consider a triple combination of hydroxychloroquine, methotrexate, and sulfasalazine. It works better than a two-drug combination methotrexate with either drug. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Is plaquenil safer than methotrexate Anyone used plaquenil and arava which is better? DailyStrength, DMARDs Disease-Modifying Antirheumatic Drugs – CreakyJoints Ophthalmologist for plaquenilWhy take hydroxychloroquine with methotrexateSarcoidosis treatment hydroxychloroquine I havent had any side effects but I guess it is early days yet. The RA is better but I am putting that down to the steroid injection rather than the plaquenil as I have been told the Plaquenil can take a few weeks to work. Its interesting to read everyone elses views on the different drug treatments lixxie7 Methotrexate or Plaquenil? DailyStrength. Choosing Medications for Rheumatoid Arthritis - NCBI Bookshelf. Methotrexate or Plaquenil - Scleroderma - Inspire. Your doctor may prescribe methotrexate alone. or you may also take other drugs like aspirin, nonsteroidal anti-inflammatory drugs, low-dose steroids, or other disease-modifying antirheumatic drugs. Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. Jul 29, 2016 Not everyone will find relief with methotrexate, but it works better for more people than other DMARDs. If methotrexate treatment didn’t work for your RA the first time, there’s still hope. A.