Chloroquine mechanism of resistance

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by haw4ik, 13-Mar-2020.

  1. bersek Moderator

    Chloroquine mechanism of resistance


    However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial rates of chloroquine accumulation are the same.

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    Chloroquine Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. These compounds belonged to a new class of antimalarials, the four-amino quinolines. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial.

    These results suggest that a higher rate of chloroquine release explains the lower chloroquine accumulation, and thus the resistance observed in resistant Plasmodium falciparum. Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.

    Chloroquine mechanism of resistance

    Drug resistance in malaria - World Health Organization, Chloroquine mechanism of drug action and resistance in.

  2. Chloroquine nursing responsibilities
  3. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely.

    • Chloroquine - Wikipedia.
    • Efflux of chloroquine from Plasmodium falciparum..
    • Chloroquine Mechanism of action and resistance in malaria 2..

    Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. The combination of chloroquine with zinc enhanced chloroquine’s cytotoxicity and induced apoptosis in A2780 cells. Thus chloroquine is a zinc ionophore, a property that may contribute to chloroquine’s anticancer activity. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. The spread of chloroquine resistance poses a serious challenge to find strategies to treat malaria. an understanding of the molecular mechanisms involved in chloroquine resistance can lead to.

     
  4. syskaserv Moderator

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  5. IMPERIAL. XenForo Moderator

    Since being diagnosed with Lupus and taking the normal meds, particularly Plaquenil and Prednisone (over about 6 years), I gained about 45 pounds. Immune & Autoimmune - Lupus want to know good stuff about plaquenil Plaquenil and hair loss. DailyStrength Hydroxychloroquine Plaquenil and Hair Loss Is my Plaquenil causing.
     
  6. ilich Guest

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.

    Hydroxychloroquine Uses, Dosage & Side Effects -