Chloroquine glutathione synthase

Discussion in 'Northwest Pharmacy Canada' started by [email protected], 15-Mar-2020.

  1. Logistic User

    Chloroquine glutathione synthase


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Glutathione synthetase is also a potent antioxidant. It is found in many species including bacteria, yeast, mammals, and plants. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, increased rate of haemolysis. Glutathione is held in a reduced state by glutathione reductase and thioredoxin. Conditions of high oxidative stress lead to depletion of glutathione, which, in turn, increases the biosyn-thetic activity of γ-glutamylcysteine synthase to restore glutathione to normal levels. Glutathione biosynthesis involves two adenosine triphosphate-dependent steps First, gamma-glutamylcysteine is synthesized from L-glutamate and cysteine. This conversion requires the enzyme glutamate–cysteine ligase GCL, glutamate cysteine synthase. This reaction is the rate-limiting step in glutathione synthesis.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine glutathione synthase

    Recruitment of glutathione into the nucleus during cell., Glutathione - an overview ScienceDirect Topics

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  4. Oct 01, 2018 The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight.

    • Chloroquine - FDA prescribing information, side effects and uses.
    • Glutathione - Wikipedia.
    • Chloroquine - Wikipedia.

    The genes encoding enzymes involved in glutathione GSH metabolism may modulate responses to antimalarial drugs, but the role of most of them in antimalarial drug resistance has scarcely been investigated. Glutathione synthase GSH2; EC 6.3.2.3. In Arabidopsis, GSH1 is exclusively targeted to the plastid, while GSH2 is targeted to both plastid and cytosol 12. Consequently, the pathway intermediate, γ-glutamylcysteine γ-EC, must be exported from the plastid to allow for cytosolic GSH biosyn-thesis. Sep 01, 2013 CQ resistance CQR is associated with mutations in the DV membrane protein P. falciparum chloroquine resistance transporter PfCRT, mediating the leakage of CQ from the DV. However, additional factors are thought to contribute to the resistance phenotype. This study tested the hypothesis that there is a link between glutathione GSH and CQR.

     
  5. AndreyOptic Well-Known Member

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  6. afrodita User

    Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar.

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