Chloroquine mechanism of action autophagy

Discussion in 'Northwest Pharmacy Canada' started by hayk, 17-Mar-2020.

  1. elektroshok Guest

    Chloroquine mechanism of action autophagy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It has also been demonstrated that chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy inhibition, and the potential side effects of chloroquine therapy have also been cautiously discussed. This indicates that a more detailed understanding of chloroquine's anticancer mechanism is required in order to further develop this compound into an effective anticancer agent. Chloroquine is one of the oldest anti-malarial agent, effectively used in malarial infections. P. falciparum and vivax are the sensitive types. It is a rapidly acting drug, targeting the asexual stage. It is an effective blood schizonticidal agent. It is gametocidal, except for P. falciparum.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action autophagy

    Chloroquine Targets Pancreatic Cancer Stem Cells via., Chloroquine Is a Zinc Ionophore - PubMed Central PMC

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  7. Chloroquine, autophagy and immune response Autophagy is an important cellular mechanism developed to degrade aged and dysfunctional proteins and organelles, as well as a mean to overcome lack of nutrients during starvation and it is also involved in eliminating some microorganisms.

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    MHY1485 has the ability to penetrate the cell. It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts. MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. The autophagy inhibitors, chloroquine and bafilomycin A1, as well as genetic suppression of the autophagic signaling proteins Atg5 or Atg 7 attenuated the impact of the combination treatment of 1. To investigate the impact of autophagy in either promoting or protecting CLL cells from death, we used chloroquine, an agent that prevents fusion of the autophagosome with the lysosome. 30 In these experiments, chloroquine did indeed inhibit autophagosome-lysosome fusion at 0.1-0.5μM, concentrations attainable in patients receiving this for malaria treatment 31 supplemental Figure 2.

     
  8. vipmodels New Member

    Please make sure that Javascript and cookies are enabled on your browser and that you are not blocking them from loading. Hydroxychloroquine Prices, Coupons & Savings Tips - GoodRx Scrap Metal Prices UK – The UK's latest scrap metal prices, updated. Chloroquine Prices, Coupons & Patient Assistance Programs -
     
  9. Splayer Guest

    Hydroxychloroquine use while Breastfeeding Apr 21, 2019 Breastfeeding infants should receive the recommended dosages of hydroxychloroquine for malaria prophylaxis.7 Drug Levels. Hydroxychloroquine is usually available as the sulfate salt with hydroxychloroquine constituting about 75% of the labeled dose of hydroxychloroquine sulfate. It has a half-life of over a month.

    Hydroxychloroquine - Drugs and Lactation Database LactMed.
     
  10. Mr.Art Well-Known Member

    Despite Plaquenil dosing recommendations, retinal toxicity. The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience.

    Protecting your eyesight when taking Plaquenil Lupus.