Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Stopping and starting plaquenil Hydroxychloroquine for systemic lupus erythematosus Hydroxychloroquine sulfate 200 mg tablet The mechanisms of chloroquine accumulation in the food vacuole have been proposed to be accumulation of chloroquine in the food vacuole as a result of increased acidity, presence of a carrier in the parasite and the presence of a receptor in the vacuole that chloroquine can bind to 10. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Chloroquine is indicated to suppress or treat acute attacks of Chloroquine is absorbed rapidly and completely from the gastro Suppress or treat acute attacks of malaria. It does not preven Absorbed rapidly by GI system. Concentrates in RBC, liver, kid It's direct effects are on the parasite. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. What is the mechanism of action of chloroquine Chloroquine phosphate C18H32ClN3O8P2 - PubChem, Chloroquine - FDA prescribing information, side effects and uses Aralen animeChloroquine phosphate dosage aquariumPlaquenil thrombocytopenia Study explains malaria origin and presents Plasmodium evolution and chloroquine mode of action on parasite. Hypotheses on the chloroquine resistance mechanism and reversion of antimalarial drug. PDF Malaria Mode of action of chloroquine and mechanism.. Chloroquine Flashcards and Study Sets Quizlet. CHLOROQUINE PHOSPHATE, USP. It is caused by protozoan parasites belonging to the Plasmodium genus and transmitted by an infected female Anopheles mosquito. This disease affects mainly children aged less than 5 years. Among the four species of malarial parasite which infect humans. Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.