One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine eye retina Hydroxychloroquine 200 mg high Hydroxychloroquine and hearing loss Introduction Hydroxychloroquine Plaquenil® is an antimalarial agent which is approved for rheumatoid arthritis, systemic lupus erythematosis, discoid lupus erythematosis, prophylaxis and treatment of acute malaria, and photodermatosis 1. In the Netherlands it has been approved since 1966. Hydroxychloroquine HQ, a quinoline compound, rarely causes ototoxicity. Its ototoxicity is associated with varying degree of destruction of the cochlear sensory hair cells, a decrease in neuronal population, alteration in supporting structures and atrophy and vacuolization of the stria vascularis as a possible consequence of ischemia 1, 2. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil ototoxicity Gentamicin Toxicity - Symptoms, Signs, Treatment, Risk Factors, A case report of hearing loss post use of hydroxychloroquine. Oral plaquenil eye examPlaquenil and eye photosensitivity Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine-Induced Retinal Toxicity - American.. The Risk of Retinal Toxicity with Plaquenil. Plaquenil Uses, Dosage & Side Effects -. The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. If you google you will find details of compounding pharmacies. What Is Ototoxicity? Certain medications can damage the ear, resulting in hearing loss, ringing in the ear, or balance disorders. These drugs are considered ototoxic. There are more than 200 known ototoxic medications prescription and over-the-counter on the market today. Plaquenil Toxicity is due to its affinity for melanin-containing structures in body. With prolonged usage, metabolites of drug accumulate in the retina.