I would think the drug has aggravated a pre-existing condition. There may be another drug that would not cause your GERD. Increased gas plaquenil Does a daily dose if plaquenil help with joint pain Plaquenil and early pregnancy Hydroxychloroquine vs malarone I have been taking plaquenil, generic also, since 2005. Like others say, rare to affect eyes, but can cause blindness that goes away when med is stopped. I have MCTD. He thinks the plaquenil 200mg and Vit D 50,000 units RX every two weeks hopefully will keep me from developing full blown lupus. At any rate, what I'm getting at is if she is on 2 pills a day she may be able to split the dose am and pm, or take it all in one lump sum -- check with your doc on whether timing is important, and if not maybe adjusting her intake can help with the tummy troubles. Plaq takes 2 - 6 months to become effective. My doctor wants me to start taking Plaquenil tomorrow. I have read some of your comments about nausea, heartburn, indigestion, and hair loss. I am wondering how long it will take to get any of these side effects if at all after I start Plaquenil? One day, one week, one month, one year? Thank. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Plaquenil is the brand name for the prescription drug hydroxychloroquine. What can i take for heartburn with plaquenil Plaquenil and Pepcid -, Nausea from Plaquenil, etc" Lupus Community - Support Group Hypoglycemia and plaquenilHydroxychloroquine mode of actionHydroxychloroquine myopathy For most Americans, heartburn is just an occasional problem. For those living with RA though, regular use of NSAIDs and medications like Methotrexate or Prednisone, the occasional heartburn becomes more of an everyday trial. This results in chronic acid reflux that causes irritation and inflammation to the lining of your esophagus, a condition known as gastroesophageal reflux disease GERD. GERD, Acid Reflux, and The Relation to Rheumatoid Arthritis. How long taking Plaquenil before side effects DailyStrength. Plaquenil Oral Uses, Side Effects, Interactions.. So far it’s been okay, no major side effects. Except today I started having some heartburn after taking it. It says on the bottle I can’t take an antacid for at least four hours after taking the Plaquenil. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. It's recommended you wait at least four hours after taking hydroxychloroquine before you take an indigestion remedy. It may take up to six months before the full benefits of Plaquenil are realized. Dosage The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more.