The pricing of generic medications for uninsured patients is irrational and counter-intuitive. Because of this, the uninsured patient can pay far too much for a generic drug. One might expect that the price of a generic medication to be “low”, and to not vary much from pharmacy to pharmacy. What inspired me to write this post is hearing from several different patients that they had paid exorbitant prices for their generic meds. Consider lamotrigine, the generic name for Lamictal, which is increasingly admired for its ability to prevent depression in bipolar II patients. A typical initial prescription for lamotrigine would be for 60 25 mg pills. At the lamotrigine page, enter your zip code (so you can see the pharmacies closest to you), the dosage of lamotrigine you’re interested in, and the number of pills you’d like to buy 4. Without insurance, the estimated cash price would be (from the Goodrx website, accessed 5/16/15: https:// Go to the Goodrx website (It is unnecessary to sign in or register) 2. In the example above, I’d enter 90403 (my office zipcode), lamotrigine 25 mg, quantity 60. The cheapest price ($13.98) is from “membership warehouse, name cannot be shown” (presumably Costco). There is no need to battle traffic in the Costco parking lot, however, because of these prices (which require printing the free coupon from the Goodrx website): Ralph’s $13.98 Pharmaca $14.08 Walgreen’s $14.38 (a 90% savings over the cash price) Von’s $14.63 But note, even with the coupon CVS $79.39 Rite Aid $107.33 7. distance=6&filter-location=&coords=&label=lamotrigine&form=tablet&strength=25mg&quantity=60.0&qty-custom=&language=&store-chain= Walgreens $149 CVS $134 Rite Aid $127. 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This changes over a period of weeks, with the efficacy building over time. Some benefits in depression may be noticed in the first 1-2 weeks, but the greatest clinical efficacy arrives in the first couple months. Zoloft is a medication known as a selective serotonin reuptake inhibitor. The mediation is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Zoloft is a selective serotonin reuptake inhibitor (SSRI). SSRIs are the most commonly prescribed type of antidepressants, and they work by increasing levels of serotonin in the brain. They are also sometimes prescribed to treat anxiety and other conditions. If you have bipolar disorder and take an SSRI, you may be at risk for triggering a manic episode if you are not also taking a mood stabilizer. 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